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Genetic Diversity and Prevalence of Plasmodium falciparum in Rivers State, Nigeria: A Comparison of Conventional Diagnostic and Molecular Method

Abstract Background: Malaria, caused by Plasmodium falciparum, remains a major health challenge, particularly in sub-Saharan Africa. Accurate diagnosis is essential for effective treatment and control, yet the performance of diagnostic techniques varies, especially in resource-limited settings. Objective: This study aimed to compare the prevalence of P. falciparum using three diagnostic methods—Rapid Diagnostic Test (RDT), microscopy, and Polymerase Chain Reaction (PCR)—and to determine the genetic diversity of P. falciparum in Rivers State, Nigeria. Methodology: A hospital-based cross-section…