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State-Level Heterogeneity in mecA Prevalence in Nigeria: A Meta-Analysis, Meta-Regression, and Empirical Validation
Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health threat in Nigeria, yet the geographic distribution and drivers of mecA-mediated resistance remain poorly characterized. While numerous individual studies have reported mecA prevalence across different regions, no comprehensive synthesis has examined the sources of heterogeneity in these estimates. This study systematically reviewed and meta-analyzed 53 studies comprising 4,630 Staphylococcus aureus isolates to determine the pooled prevalence of the mecA gene in Nigeria. The primary objective was to identify whether geo…
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